Glycotope Poster Presentation at the 2021 American Society of Clinical Oncology (ASCO) Virtual Annual Meeting

Berlin, Germany, June 4, 2021 – Glycotope GmbH, a biotechnology company developing antibodies against proteins carrying tumor-specific carbohydrate structures, today announcedit is presenting two posters at the 2021 American Society of Clinical Oncology (ASCO) Annual Meeting, which is being held virtually this year due to COVID-19.

Henner Kollenberg, Managing Director of Glycotope GmbH commented: “The data presented at ASCO highlight our ability to draw on our long-standing expertise in glyco-biology to generate novel biopharmaceuticals targeting cancer indications. The data showed that a Glycotope-developed anti-TA-MUC1 antibody combined with the anti-EGFR Tomuzotuximab or Panitumumab in patients with refractory solid tumors is safe and feasible and exhibited interesting anti-tumour activity.”

Poster details are as follows:

Poster 2524

Title: Safety and tolerability results of the GATTO study, a phase Ib study combining the anti-TA-MUC1 antibody Gatipotuzumab with the anti-EGFR Tomuzotuximab or Panitumumab in patients with refractory solid tumors
Session: Poster Session: Developmental Therapeutics—Immunotherapy
Abstract ID: 332635

Download: https://www.glycotope.com/glycotope-poster-presentation-at-the-2021-american-society-of-clinical-oncology-asco-virtual-annual-meeting-poster2524/

Poster 2522
Title: Activity results of the GATTO study, a phase Ib study combining the anti-TA-MUC1 antibody Gatipotuzumab with the anti-EGFR Tomuzotuximab or Panitumumab in patients with refractory solid tumors

Session: Poster Session: Developmental Therapeutics—Immunotherapy
Abstract ID: 329709

Download: https://www.glycotope.com/glycotope-poster-presentation-at-the-2021-american-society-of-clinical-oncology-asco-virtual-annual-meeting-poster2522/

Contact Information:

Contact Information:

Glycotope GmbH
Henner Kollenberg
Managing Director
Phone: +49 30 9489 2600
E-Mail: contact@glycotope.com

Media Contact:
Chris Gardner, Chris Welsh
Consilium Strategic Communications
Phone: +44 (0) 20 3709 5700
Email: glycotope@consilium-comms.com

About GATTO

The multicenter, open label phase Ib GATTO study explored the feasibility, tolerability and preliminary activity of combining Gatipotuzumab, a novel humanized monoclonal antibody binding to a tumor-associated epitope of mucin-1 (TA-MUC1) and an anti-EGFR antibody. Based on compelling preclinical evidence suggesting a complex interaction between EGFR and TA-MUC1 expressed on the tumor cell surface in driving carcinogenesis, this study assessed the tolerability, safety and preliminary activity of targeting EGFR and TA-MUC1. In this study, 50 patients with refractory solid tumors were treated with both antibodies in 5 centers in Germany, Italy and Spain.

The results analysis demonstrated that combination of TA-MUC1 and EGFR targeting antibodies is safe and feasible. Encouraging anti-tumor activity was observed in heavily pretreated NSCLC and CRC patients, particularly when the commercial anti-EGFR Panitumumab was used in combination with Gatipotuzumab. Levels of soluble TA-MUC1 may have predictive value and potentially be a companion biomarker for further development of the combination.

About Glycotope

Glycotope is a biotechnology company utilizing a proprietary technology platform to develop uniquely tumor-specific monoclonal antibodies. Our antibodies target specific tumor-associated carbohydrate structures or protein/carbohydrate combined glyco-epitopes (GlycoTargets). Glycotope has to date discovered in excess of 150 GlycoTargets with antibodies against several of these targets currently under development.

Based on their superior tumor-specificity, our antibodies are suitable for development in an array of different modes of action including naked antibodies, bispecifics, antibody-drug-conjugates, cellular therapies or fusion-proteins.

Currently six clinical and pre-clinical programs based on the TA-MUC1 GlycoTarget are under development by Glycotope or its licensing partners. Visit www.glycotope.com.